tsRNADisease

Entry Detail

General Information

Database ID:	TRD00381
Confidence:	High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

5'tiRNA-33-CysACA-1

tsRNA Type:

5'-tiRNA

Amino acid and Anticodon:

N/A

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	1 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	N/A	DOID:10779
Disease Name:	N/A	septic myocarditis
Category:	MeSH	Disease Ontology
Type:	N/A	disease of anatomical entity//thoracic disease
Define:	N/A	An acute myocarditis that is characterized by an underlying infectious insult to the myocardium that induces acute inflammation.
Alias:	N/A	N/A

Disease Association Statistics

Total Associated tsRNA Number:	1 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	PCR//Western blot
Weak Evidence:	Data Mining

Reference

[1] PubMed ID:	39631469
Disease Name:	septic myocarditis
Tissue:	Heart
Dysfunction Pattern:	Up-Regulation
Validated Method:	PCR//Western blot//Data Mining
Description:	Our study suggests that 5'tiRNA-33-CysACA-1 expression is elevated in SCM and leads to impaired mitochondrial function in cardiomyocytes.
Comparision:	Disease VS Control
Mechanism:	Our study suggests that 5'tiRNA-33-CysACA-1 expression is elevated in SCM and leads to impaired mitochondrial function in cardiomyocytes. Mechanistically, 5'tiRNA-33-CysACA-1 contributes to the development of SCM by targeting peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), a key molecule for mitochondrial biogenesis, and affecting the stability of PGC-1α mRNA and leading to a hindrance in mitochondrial biogenesis.