Entry Detail


General Information

Database ID:TRD00347
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tiRNA-Val-CAC-002
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:ValCAC
Sequence:GTTTCCGTAGTGTAGCGGTTATCACATTCGCCTC
Related Target:PI3K-Akt
Predicted Target:PLEKHG5//CDYL2//KLK10//GPC6//GALNTL6//ILRUN//SOCS2//SNX1//TRERF1//CIAO3
External Links:
MINTbase ID:tRF-34-79MP9PMNH5IS15
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Val-CAC-3-1
Anticodon:ValCAC
tRNA_number:trna13
Chromosome:19
Strand:-
Coordinate:Start Site(bp): 4724686        End Site(bp): 4724719



tsRNA Association Statistics

Total Associated Disease Number:25
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009914DOID:5773
Disease Name:Oral Submucous Fibrosisoral submucous fibrosis
Category:MeSHDisease Ontology
Type:Stomatognathic Diseasesdisease of anatomical entity
Define:Irreversible FIBROSIS of the submucosal tissue of the MOUTH.A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.
Alias:N/AOral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongue



Disease Association Statistics

Total Associated tsRNA Number:126
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34558114
Disease Name:Oral Submucous Fibrosis
Tissue:Osf Tissue
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Of 126 tsRNAs in OSF were dysregulated, including 73 upregulated tsRNAs and 53 downregulated tsRNAs. The downregulated tiRNA-Val-CAC-002,tRF-Asn-GTT-005, tRF-Trp-CCA-007 and upregulated tRF-Gly-TCC-016,tRF-Pro-TGG-009 showed significant differences by qRT-PCR validation.
Comparision:Disease VS Normal
Mechanism:tiRNA-Val-CAC-002, as a suppressor of oncogenic cytokines, might be mainly involved in the transition from OSF to OSCC.