Entry Detail


General Information

Database ID:TRD00206
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tiRNA-5HisGTG
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:HisGTG
Sequence:N/A
Related Target:Musashi-1; Mpc1
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:8
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003920DOID:9351
Disease Name:Diabetes Mellitusdiabetes mellitus
Category:MeSHDisease Ontology
Type:Nutritional and Metabolic Diseases//Endocrine System Diseasesdisease of metabolism//genetic disease
Define:A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:47
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing//Data Mining



Reference

[1] PubMed ID:35830789
Disease Name:Diabetes Mellitus
Tissue:Islets of Neonatal And Adult Rats
Dysfunction Pattern:N/A
Validated Method:RT-PCR//High-throughput sequencing//Data Mining
Description:Altogether, tiRNA-5s represent a class of regulators of β cell maturation, and their deregulation in neonatal islets may lead to diabetes susceptibility in adulthood.
Comparision:N/A
Mechanism:tiRNA-5 inhibition reduced Mpc1, a mitochondrial pyruvate carrier whose knock down largely phenocopied tiRNA-5 inhibition. tiRNA-5HisGTG interactome revealed binding to Musashi-1, which was essential for the mitochondrial enrichment of tiRNA-5HisGTG. Finally, tiRNA-5s were dysregulated in the islets of diabetic and diabetes-prone animals. Altogether, tiRNA-5s represent a class of regulators of b cell maturation, and their deregulation in neonatal islets may lead to diabetes susceptibility in adulthood.