Entry Detail


General Information

Database ID:TRD00203
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:5'tiRNA‐His‐GTG
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:HisGTG
Sequence:N/A
Related Target:CYP2E1
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003930DOID:13207
Disease Name:Diabetic Retinopathyproliferative diabetic retinopathy
Category:MeSHDisease Ontology
Type:Eye Diseases//Cardiovascular Diseases//Endocrine System Diseasesdisease of anatomical entity//nervous system disease
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.N/A
Alias:N/APDR



Disease Association Statistics

Total Associated tsRNA Number:86
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:39513253
Disease Name:Diabetic Retinopathy
Tissue:retina
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Western blot//High-throughput sequencing
Description:Ere, we clarify the significance of a tRNA‐derived stress‐induced small RNA, 5′tiRNA‐His‐GTG, which is up‐regulated during the progression of DR. Up‐regulation of 5′tiRNA‐His‐GTG accelerates retinal vascular dysfunction, exacerbates retinal neurodegeneration, and impairs visual function and visually‐guided behaviors in diabetic mice.
Comparision:Disease VS Control
Mechanism:Echanistically, down‐regulation of 5′tiRNA‐His‐GTG causes a marked reduction of AA metabolism‐modulated cytochrome P450 (CYP) pathway by decreasing CYP2E1 expression. Furthermore, the 5′tiRNA‐His‐GTG‐CYP2E1‐19(S)‐HETE signaling axis is implicated in retinal neurovascular dysfunction. Collectively, this study suggests that down‐regulation of 5′tiRNA‐His‐GTG holds therapeutic promise in rescuing visual function by neurovascular protection.