Entry Detail



General Information

Database ID:TRD00175
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tiRNA-Gly-GCC-001
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:GlyGCC
Sequence:GCATAGGTGGTTCAGTGGTAGAATTCTTGCCTG
Related Target:N/A
Predicted Target:FCGR2A//LHX8//ZNF513//NDUFAF1//ZNF778//KCTD9//ERAS//SPRN//SORCS1//ARPP21
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:12
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D003865DOID:1470
Disease Name:Depressive Disorder, Majormajor depressive disorder
Category:MeSHDisease Ontology
Type:Mental Disordersdisease of mental health
Define:Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality.
Alias:Depression, Involutional//Major Depressive Disorder//Melancholia, Involutional//Paraphrenia, Involutional//Psychosis, Involutionalclinical depression//major depression//recurrent major depression//single major depressive episode//unipolar depression



Disease Association Statistics

Total Associated tsRNA Number:93
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38439581
Disease Name:Depressive Disorder, Major
Tissue:Blood
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:qRT-PCR validation confirmed that major tiRNA up-regulation was evident within the serum of patients with MDD compared to that in control individuals (Figure 7a).
Comparision:MDD VS Normal
Mechanism:N/A