tsRNADisease

Entry Detail

General Information

Database ID:	TRD00167
Confidence:	High
Contents:	>> tsRNA Information >> tsRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference

tsRNA Information

tsRNA Name:

SHOT-RNA

tsRNA Type:

5'-tiRNA

Amino acid and Anticodon:

GlyGCC

Sequence:

N/A

Related Target:

Predicted Target:

External Links:

MINTbase ID:	N/A
tRFdb ID:	N/A

tsRNA Association Statistics

Total Associated Disease Number:	4 More Information
Network: (Display the first 15 nodes)

Disease Information

	MeSH	Disease Ontology
Disease ID:	D011471	DOID:2526
Disease Name:	Prostatic Neoplasms	prostate adenocarcinoma
Category:	MeSH	Disease Ontology
Type:	Neoplasms//Urogenital Diseases	disease of anatomical entity//disease of cellular proliferation
Define:	Tumors or cancer of the PROSTATE.	A prostate carcinoma that derives_from epithelial cells of glandular origin.
Alias:	Cancer of Prostate//Cancer of the Prostate//Neoplasms, Prostate//Neoplasms, Prostatic//Prostate Cancer//Prostate Neoplasms//Prostatic Cancer	N/A

Disease Association Statistics

Total Associated tsRNA Number:	119 More Information
Network: (Display the first 15 nodes)

Evidence Support

Strong Evidence:	RT-PCR
Weak Evidence:	N/A

Reference

[1] PubMed ID:	26124144
Disease Name:	Prostatic Neoplasms
Tissue:	Prostatic
Dysfunction Pattern:	Up-Regulation
Validated Method:	RT-PCR
Description:	SHOT-RNAs were prominently and constitutively enriched only in ER+ breast cancer and AR+ prostate cancer cell lines, whereas ER− breast cancer, AR− prostate cancer, and all examined cancer cell lines from other tissues expressed low levels of tRNA halves;
Comparision:	Cancer VS Control
Mechanism:	We propose the model that the sex hormone-signaling pathways activate ANG cleavage of aminoacylated mature tRNAs, and the resultant accumulation of SHOT-RNAs contributes to cell proliferation and thereby may promote tumorigenesis and tumor growth (Fig. 7B).