Entry Detail


General Information

Database ID:TRD00166
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:SHOT-RNA
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:GlyGCC
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:4
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D001943DOID:1612
Disease Name:Breast Neoplasmsbreast cancer
Category:MeSHDisease Ontology
Type:Neoplasms//Skin and Connective Tissue Diseasesdisease of anatomical entity//disease of cellular proliferation
Define:Tumors or cancer of the human BREAST.A thoracic cancer that originates in the mammary gland.
Alias:Breast Cancer//Breast Carcinoma//Breast Tumors//Cancer of Breast//Cancer of the Breast//Human Mammary Carcinoma//Malignant Neoplasm of Breast//Malignant Tumor of Breast//Mammary Cancer//Mammary Carcinoma, Human//Mammary Neoplasm, Human//Mammary Neoplasms, Human//Neoplasms, Breast//Tumors, Breastbreast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary neoplasm//mammary tumor//primary breast cancer



Disease Association Statistics

Total Associated tsRNA Number:549
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:N/A



Reference

[1] PubMed ID:26124144
Disease Name:Breast Neoplasms
Tissue:Breast
Dysfunction Pattern:Up-Regulation
Validated Method:RT-PCR
Description:SHOT-RNAs were prominently and constitutively enriched only in ER+ breast cancer and AR+ prostate cancer cell lines, whereas ER− breast cancer, AR− prostate cancer, and all examined cancer cell lines from other tissues expressed low levels of tRNA halves;
Comparision:Cancer VS Control
Mechanism:We propose the model that the sex hormone-signaling pathways activate ANG cleavage of aminoacylated mature tRNAs, and the resultant accumulation of SHOT-RNAs contributes to cell proliferation and thereby may promote tumorigenesis and tumor growth (Fig. 7B).