Entry Detail


General Information

Database ID:TRD00164
Confidence:Median
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:AS-tDR-001289
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:GlyGCC
Sequence:GCATGGGTGGTTCAGTGGTAGAATTCTCGCCT
Related Target:N/A
Predicted Target:FCGR2A//B4GALNT4//LPAR1//AATK//DPF1//ZNFX1//NLGN3//EIF3G//NDUFAF1//WDFY4
External Links:
MINTbase ID:tRF-32-P4R8YP9LON4V3
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Gly-GCC-1-1
Anticodon:GlyGCC
tRNA_number:trna35
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161413094        End Site(bp): 161413125

[2] gtRNAdb_ID:tRNA-Gly-GCC-1-2
Anticodon:GlyGCC
tRNA_number:trna37
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161420467        End Site(bp): 161420498

[3] gtRNAdb_ID:tRNA-Gly-GCC-1-3
Anticodon:GlyGCC
tRNA_number:trna39
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161427898        End Site(bp): 161427929

[4] gtRNAdb_ID:tRNA-Gly-GCC-1-4
Anticodon:GlyGCC
tRNA_number:trna41
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 161435258        End Site(bp): 161435289

[5] gtRNAdb_ID:tRNA-Gly-GCC-1-5
Anticodon:GlyGCC
tRNA_number:trna2
Chromosome:21
Strand:-
Coordinate:Start Site(bp): 18827146        End Site(bp): 18827177



tsRNA Association Statistics

Total Associated Disease Number:16
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D012214DOID:0050827
Disease Name:Rheumatic Heart Diseaserheumatic heart disease
Category:MeSHDisease Ontology
Type:Infections//Cardiovascular Diseasesdisease of anatomical entity
Define:Cardiac manifestation of systemic rheumatological conditions, such as RHEUMATIC FEVER. Rheumatic heart disease can involve any part the heart, most often the HEART VALVES and the ENDOCARDIUM.A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.
Alias:Bouillaud Disease//Bouillaud's Diseaserheumatic carditis



Disease Association Statistics

Total Associated tsRNA Number:66
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:N/A
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34926598
Disease Name:Rheumatic Heart Disease
Tissue:Heart
Dysfunction Pattern:Down-Regulation
Validated Method:High-throughput sequencing
Description:Fourteen tsRNAs (4 up-regulated: AS-tDR-001270, AS-tDR-001297, AS-tDR-001269, and AS-tDR-001289; 10 down-regulated: AS-tDR-000205, AS-tDR-000123, AS-tDR-007294, AS-tDR-007326, AS-tDR-007245, AS-tDR-000102, AS-tDR-006049, AS-tDR-001363, AS-tDR-000886, AS-tDR-000894) were significantly altered in RHD with the AF group compared with RHD without AF group (Figure 3B, Table 1).
Comparision:AF RHD VS NAF RHD
Mechanism:Data Mining uncovered the altered biological functions, including regulation of transcription, DNA binding, intracellular, and cytokine-cytokine receptor interaction. These results aimed to explore the regulatory role of tsRNAs in RHD with AF.