Entry Detail


General Information

Database ID:TRD00122
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tiRNA-Glu-TTC-003
tsRNA Type:5'-tiRNA
Amino acid and Anticodon:GluTTC
Sequence:TCCCTGGTGGTCTAGTGGCTAGGATTCGGCGCTT
Related Target:N/A
Predicted Target:PAQR4//TMEM69//RFTN1//BAHCC1//DDX60//TFCP2L1//PHETA1//CHRNB4//SLC25A6//EME2
External Links:
MINTbase ID:tRF-34-87R8WP9I1EWJIQ
tRFdb ID:N/A

[1] gtRNAdb_ID:tRNA-Glu-TTC-8-1
Anticodon:GluTTC
tRNA_number:trna94
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 149664394        End Site(bp): 149664427

[2] gtRNAdb_ID:tRNA-Glu-TTC-4-1
Anticodon:GluTTC
tRNA_number:trna134
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 16861812        End Site(bp): 16861845

[3] gtRNAdb_ID:tRNA-Glu-TTC-4-2
Anticodon:GluTTC
tRNA_number:trna84
Chromosome:1
Strand:-
Coordinate:Start Site(bp): 161391921        End Site(bp): 161391954

[4] gtRNAdb_ID:tRNA-Glu-TTC-3-1
Anticodon:GluTTC
tRNA_number:trna5
Chromosome:1
Strand:+
Coordinate:Start Site(bp): 17199078        End Site(bp): 17199111



tsRNA Association Statistics

Total Associated Disease Number:16
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D009765DOID:9970
Disease Name:Obesityobesity
Category:MeSHDisease Ontology
Type:Nutritional and Metabolic Diseases//Pathological Conditions, Signs and Symptomsdisease of metabolism
Define:A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
Alias:N/AN/A



Disease Association Statistics

Total Associated tsRNA Number:55
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:37352603
Disease Name:Obesity
Tissue:Brown Adipocytes
Dysfunction Pattern:Down-Regulation
Validated Method:RT-PCR//High-throughput sequencing
Description:Further, qRT-PCR validated that three notably upregulated tRFs (tRF-Gly-GCC-007, tRF-Gly-GCC-008, and tRF-Gly-GCC-016) were in accordance with the sequencing result.
Comparision:Forskolin VS Control
Mechanism:Target genes of tRFs were involved in positive regulation of protein phosphorylation and cell adhesion process by significantly downregulating UCHL10 expression, which might participate in lipolysis. This study might provide therapeutic targets and potential diagnostic biomarkers for obesity treatment.