Entry Detail


General Information

Database ID:TRD00045
Confidence:Very High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRNA-ThrCGT
tsRNA Type:3'-tiRNA
Amino acid and Anticodon:ThrCGT
Sequence:N/A
Related Target:N/A
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D008180DOID:9074
Disease Name:Lupus Erythematosus, Systemicsystemic lupus erythematosus
Category:MeSHDisease Ontology
Type:Skin and Connective Tissue Diseases//Immune System Diseasesdisease of anatomical entity
Define:A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart.
Alias:Libman-Sacks Disease//Lupus Erythematosus Disseminatus//Systemic Lupus Erythematosusdisseminated lupus erythematosus//Lupus Erythematosus, systemic//SLE - Lupus Erythematosus, systemic



Disease Association Statistics

Total Associated tsRNA Number:111
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Transfection//Luciferase reporter assay//RIP//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:34256772
Disease Name:Lupus Erythematosus, Systemic
Tissue:Blood
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Transfection//Luciferase reporter assay//RIP//Western blot//High-throughput sequencing
Description:The original goal of this study was to study small RNAs in CD4+ T cells of SLE patients. Surprisingly, in addition to some miRNAs with well-known function, the small RNA sequencing data also showed a series of tRNA derived fragments(tRFs). This is the first study to identify differentially expressed tRFs in CD7+ T cells from SLE patients, which caught our attention. As a new category of small ncRNAs, the potential function of tRFs in the SLE pathogenesis was explored.
Comparision:Disease VS Control
Mechanism:+ T cells. This prompted us to think about the role of tRFs in the pathogenesis of SLE. The correlation between tRNA fragment and clinical indicators of SLE was analyzed, amongst these tRNA fragments, tRF-3009, a small fragment (18nt long) processed from the 3′ end of mature tRNA-Leu, was positively correlated with SLEDAI, active lupus nephritis, and the serum IFN-α level, but showed no significant relationship with different treatments in SLE. The correlations with SLEDAI and active lupus nephritis suggested that tRF-3009 may be related to the severity of disease and existence of nephritis. Moreover, the correlation with serum IFN-α level suggested that the expression or function of tRF-3012 may be related to IFN signaling pathway in lupus. Limited by the number of patients, we are unable to determine the potential of this molecule as a disease biomarker this time, which would be our next research goal.