| [1] PubMed ID: | 38894581 |
| Disease Name: | Bladder Cancer |
| Tissue: | Bladder |
| Dysfunction Pattern: | N/A |
| Validated Method: | RT-PCR//Northern blot//Western blot//RNA Pulldown//High-throughput sequencing |
| Description: | Currently, the functional role of m7G‐modified tsRNAs in tumors is unknown. In the present study, we identified mtiRL as a novel m7G‐modified tsRNA in transformed urothelial and BC cells for the first time and found that mtiRL was highly expressed in BC and involved in BC malignancy. |
| Comparision: | Disease VS Control |
| Mechanism: | Our in vitro and in vivo assays further indicated that mtiRL promotes BC growth. To probe the underlying mechanism, we performed a series of experiments and found that mtiRL specifically interacts with ANXA2 and increases the expression of p‐ANXA2‐Y24, but not total ANXA2. We further showed that mtiRL can enhance the binding between ANXA2 and Yes1, which phosphorylates ANXA2 at Tyr24. Collectively, these results describe the functional roles and regulatory mechanism of mtRL, which has an oncogenic role in BC. |
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