Entry Detail


General Information

Database ID:TRD00021
Confidence:High
Contents:>> tsRNA Information
>> tsRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference



tsRNA Information

tsRNA Name:tRF-1-AspGTC
tsRNA Type:3'-tiRNA
Amino acid and Anticodon:AspGTC
Sequence:N/A
Related Target:WNT5A//CASP3
Predicted Target:N/A
External Links:
MINTbase ID:N/A
tRFdb ID:N/A



tsRNA Association Statistics

Total Associated Disease Number:1
More Information
Network:
(Display the first 15 nodes)



Disease Information

 MeSHDisease Ontology
Disease ID:D006976DOID:6432
Disease Name:Hypertension, Pulmonarypulmonary hypertension
Category:MeSHDisease Ontology
Type:Respiratory Tract Diseases//Cardiovascular Diseasesdisease of anatomical entity
Define:Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries.
Alias:Pulmonary HypertensionN/A



Disease Association Statistics

Total Associated tsRNA Number:1
More Information
Network:
(Display the first 15 nodes)



Evidence Support

Strong Evidence:RT-PCR//Transfection//Luciferase reporter assay//RIP//Western blot
Weak Evidence:High-throughput sequencing



Reference

[1] PubMed ID:38747146
Disease Name:Hypertension, Pulmonary
Tissue:Lung
Dysfunction Pattern:N/A
Validated Method:RT-PCR//Transfection//Luciferase reporter assay//RIP//Western blot//High-throughput sequencing
Description:Our study highlights the role of site-specific 8-oxoguanine–modified tRF in promoting the development of PH.
Comparision:Disease VS Control
Mechanism:This modification occurs at the position 5 of the tRF-1-AspGTC (5o8G tRF). Inhibition of the 5o8G tRF reversed hypoxia-induced proliferation and apoptosis resistance in pulmonary artery smooth muscle cells. Further investigation unveiled that the 5o8G tRF retargeted mRNA of WNT5A (Wingless-type MMTV integration site family, member 5A) and CASP3 (Caspase3) and inhibited their expression. Ultimately, BMPR2 (Bone morphogenetic protein receptor 2) -reactive oxygen species/5o8G tRF/WNT5A signaling pathway exacerbated the progression of PH.